ISO 10298:2018

Overview

ISO 10298:2018 - Gas cylinders - Gases and gas mixtures - Determination of toxicity for the selection of cylinder valve outlets provides a consolidated, literature‑based listing of the best available acute inhalation toxicity data (LC50) for gases and vapours. The standard is intended to support the classification of pure gases and gas mixtures by inhalation toxicity so that appropriate cylinder valve outlets and safety measures can be selected.

Key topics

• Scope and purpose: Compiles validated acute‑toxicity (LC50) data from the open literature to enable toxicity classification for valve‑outlet selection.
• LC50 basis: LC50 values in the standard correspond to 1‑hour exposures (rat data preferred). Where necessary, time‑adjustment principles (Haber’s rule and variants) are applied to align different exposure durations.
• Toxicity subdivisions: Defines toxicity groups used for valve selection and transport:
  • Subdivision 1: non‑toxic (LC50 > 5 000 ppm)
  • Subdivision 2: toxic (200 ppm