EN ISO 10298:2020 PDF

Name: EN ISO 10298:2020 — Gas cylinders - Gases and gas mixtures - Determination of toxicity for the selection of cylinder valve outlets (ISO 10298:2018)
SKU: EN ISO 10298:2020
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Gas cylinders - Gases and gas mixtures - Determination of toxicity for the selection of cylinder valve outlets (ISO 10298:2018)

Название (английский):

EN ISO 10298:2020

Gas cylinders - Gases and gas mixtures - Determination of toxicity for the selection of cylinder valve outlets (ISO 10298:2018)

Статус документа:: Действующий
Формат:: Электронный (PDF)
Количество страниц:: 23
Дата публикации:: 7 октября 2020 г.
Издание:: CEN EN 10298 edition 1 version 1
ICS:: 23.020.35

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Срок поставки:4 раб. дн. (перевод)

Цена:345 €

Описание (английский):

ISO 10298:2018 lists the best available acute-toxicity data of gases taken from a search of the current literature to allow the classification of gases and gas mixtures for toxicity by inhalation.

Abstract

Overview

Key topics and requirements

Scope and purpose: Compile reliable acute-toxicity data from literature to classify gases and gas mixtures for inhalation toxicity.
Toxicity metrics: Defines key terms such as LC50, LCLO, LD50 and toxicity levels (Subdivision 1–3) used for cylinder valve selection and transport classification.
Exposure basis: LC50 values in Annex B correspond to 1 hour exposure (typically in albino rats). Conversion guidance for other exposure times is provided (Annex A).
Time adjustment principles: Explains use of Haber's rule and a square‑root time adjustment approach when converting between exposure durations; notes the conversion convention used when relating ISO values to GHS 4‑hour categories.
Mixture calculation: Specifies a calculation method to estimate a gas-mixture LC50 from component LC50s and component mole fractions (Formula in Clause 4.3). Synergistic effects are not accounted for in the formula.
Data quality and test methods: Recommends use of internationally recognized test methods (e.g., OECD TG 403) for new toxicity data and discusses animal‑welfare considerations-use calculation when component data are available.
Annexes:
- Annex A - guidance on selecting LC values and time extrapolation,
- Annex B - tabulated LC50 values for toxic gases and vapours.

Applications and users

EN ISO 10298:2020 is used by:

Cylinder and valve manufacturers to determine compatible valve outlet types according to toxicity classifications.
Industrial gas suppliers for classification and labelling of gas cylinders.
Safety engineers, EHS professionals and risk assessors evaluating inhalation hazards.
Regulatory and transport authorities referencing toxicity data for classification (including alignment with GHS categories).
Standards committees and laboratories generating or validating inhalation toxicity data.

Related standards

ISO 5145 - valve outlet dimensions for gas cylinders.
ISO 14456 - criteria for compatible gas groups.
GHS (Globally Harmonized System) - classification guidance for inhalation toxicity (4 h basis).
OECD TG 403 - inhalation toxicity test method.

Keywords: EN ISO 10298:2020, ISO 10298:2018, gas cylinders, toxicity, LC50, cylinder valve outlets, gas mixtures, inhalation toxicity, GHS, ISO 5145.

Технические детали

Технический комитет: CEN/TC 23 - Transportable gas cylinders
SKU: EN ISO 10298:2020

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ISO 10298:2018

Действующий

Gas cylinders — Gases and gas mixtures — Determination of toxicity for the selection of cylinder valve outlets

Overview ISO 10298:2018 - Gas cylinders - Gases and gas mixtures - Determination of toxicity for the selection of cylinder valve outlets provides a consolidated, literature‑based listing of the best…

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