EN ISO 10298:2020/A1:2022 PDF

Overview

EN ISO 10298:2020/A1:2022 (ISO 10298:2018/Amd 1:2021) is an amendment to the international standard for gas cylinders that provides authoritative guidance on the determination of toxicity for gases and gas mixtures to support the selection of cylinder valve outlets. The standard compiles best-available acute inhalation toxicity data from the literature so that gases and mixtures can be classified for toxicity by inhalation and appropriate valve outlet types can be selected to reduce handling and exposure risks.

Key topics and requirements

• Purpose: Use acute-toxicity data to classify gases/gas mixtures by inhalation toxicity for safe cylinder valve outlet selection.
• Data basis: Best-available LC50 (lethal concentration) values from current literature; emphasis on acute inhalation toxicity.
• Mixture calculation: Amendment 1 updates the mixture toxicity formula in clause 4.3. The revised formula for estimating the mixture LC50 is:
  • 1/LC50 = Σi (Ci / LC50i)
  • where Ci is the mole fraction of the i‑th toxic component and LC50i is the lethal concentration of that component (applicable when LC50i