ISO 10801:2010 PDF

Name: ISO 10801:2010 — Nanotechnologies — Generation of metal nanoparticles for inhalation toxicity testing using the evaporation/condensation method
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Nanotechnologies — Generation of metal nanoparticles for inhalation toxicity testing using the evaporation/condensation method

Название (английский):

ISO 10801:2010

Nanotechnologies — Generation of metal nanoparticles for inhalation toxicity testing using the evaporation/condensation method

Статус документа:: Действующий
Формат:: Электронный (PDF)
Количество страниц:: 22
Дата публикации:: 2 декабря 2010 г.
Издание:: ISO IS 10801 edition 1 version 1
ICS:: 07.030

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Описание (английский):

ISO 10801:2010 gives requirements and recommendations for generating metal nanoparticles as aerosols suitable for inhalation toxicity testing by the evaporation/condensation method. Its application is limited to metals such as gold and silver which have been proven to generate nanoparticles suitable for inhalation toxicity testing using the technique specified.

Abstract

Похожие стандарты

Стандарты, упомянутые в описании

Overview

ISO 10801:2010 - Nanotechnologies - Generation of metal nanoparticles for inhalation toxicity testing using the evaporation/condensation method - specifies requirements and recommendations for producing metal nanoparticle aerosols suitable for inhalation toxicity testing. The standard focuses on the evaporation/condensation method (evaporate a metal vapor, then cool to nucleate and condense nanoparticles) and is applicable to metals demonstrated to work with this technique, notably silver and gold. Annex A contains a worked example for silver; generated aerosols can provide stable particle size distributions (sizes up to ~100 nm) and continuous operation suitable for studies up to 90 days.

Key topics and technical requirements

Generation principle: Evaporation of a metal precursor followed by controlled quench/condensation to form nanoparticles.

System preparation and control: Parameters such as evaporation temperature, carrier flow, quench length and temperature gradients must be selected and controlled to achieve stable aerosol output.

Nanoparticle properties: Requirements and characterization for particle size distribution, number concentration, shape, purity/impurities, stability, and suitability for inhalation studies.

Performance characterization:

Size distribution measurement using DMAS (differential mobility analysing system) / DEMC (differential electrical mobility classifier) and detectors such as CPC (condensation particle counter).
Filter sampling and microscopy for mass concentration and morphology.
Guidance on sampling frequency and interfaces to exposure chambers to avoid sampling bias and deposition loss.

Exposure systems: Preparation and compatibility with inhalation exposure chambers (whole‑body, head/neck-only or nose-only) and monitoring to meet OECD inhalation test guidance.

Safety and operational requirements: Capacity control, atmosphere monitoring, and system operational safety for continuous exposure testing.

Reporting: Requirements for documenting methods, characterization data and test results.

Practical applications and users

ISO 10801:2010 is relevant to:

Toxicologists and inhalation exposure researchers conducting animal inhalation studies (acute to subchronic).

Aerosol scientists and laboratory engineers designing or operating evaporation/condensation nanoparticle generators.

Occupational hygiene and safety professionals evaluating worker exposure to engineered metal nanoparticles.

Manufacturers of nanoparticle generation systems and instrument vendors validating generator performance.

Regulators and test laboratories implementing standardized methods for nanomaterial inhalation toxicity testing.

Related standards and references

ISO/TS 27687 - Nanotechnologies terminology

ISO 15900 - Differential electrical mobility analysis

ISO/IEC 17025 - Laboratory competence

OECD Test Guidelines: TG 403, TG 412, TG 413 for inhalation toxicity studies

Keywords: ISO 10801:2010, nanotechnologies, metal nanoparticles, evaporation/condensation method, inhalation toxicity testing, silver nanoparticles, gold nanoparticles, aerosol generation, DMAS, CPC, DEMC.

ISO 10801:2010 PDF

Abstract

Похожие стандарты

Overview

Key topics and technical requirements

Practical applications and users

Related standards and references

Технические детали

ISO/TS 27687:2008

Nanotechnologies — Terminology and definitions for nano-objects — Nanoparticle, nanofibre and nanoplate

BS ISO 15900:2009

Determination of particle size distribution. Differential electrical mobility analysis for aerosol particles

ISO 6141:2015/Amd 1:2020

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