ISO 19851:2025 PDF

Overview

ISO 19851:2025 - Traditional Chinese medicine - Cinnamomum cassia branch is an international standard that defines quality and safety requirements for the dried young branch of Cinnamomum cassia Presl used as natural medicine and decoction pieces in international trade. The standard supports consistent identification, testing and handling of Cinnamomum cassia branch to protect clinical effectiveness and facilitate cross-border commerce.

Key topics and technical requirements

The standard addresses morphological, microscopic, chemical and safety characteristics, including:

• Identity and description

  • Macroscopic features (size, colour, bark and wood appearance, aroma and taste).
  • Microscopic transverse section and powder characteristics (epidermis, cork, stone cells, oil cells, phloem, xylem rays).

• Phytochemical and marker testing

  • Use of cinnamaldehyde as a marker compound related to biological activity.
  • Thin-layer chromatography (TLC) identification (Annex A) and an HPLC method for cinnamaldehyde determination (Annex B).

• Standardized physicochemical tests

  • Moisture, total ash, ethanol-soluble extractives and other extractive determinations.

• Safety limits and contaminant testing

  • Determination of heavy metals, pesticide residues, and sulfur dioxide residues, with referenced ISO test methods for these analyses.

• Quality control and sampling

  • Sampling procedures, test methods, reporting requirements, and instructions for packaging, storage, transportation, marking and labelling.

• Species differentiation

  • Guidance to differentiate Cinnamomum cassia branch from similar species such as Cinnamomum burmanni (Annex C), and examples of national/regional quality values (Annex D).

Practical applications and users

ISO 19851:2025 is intended for organizations involved in the production, testing, trade and regulation of Traditional Chinese Medicine (TCM) herbal materials, including:

• Herbal raw material producers and processors
• Quality control and analytical laboratories (TLC, HPLC, heavy metal and pesticide testing)
• Exporters, importers and distributors of Chinese materia medica
• Regulatory authorities and standards bodies harmonizing TCM quality criteria
• Manufacturers of TCM preparations and compound formulations
• Practitioners and institutions seeking assurance of herb identity and safety

Related standards

ISO 19851 references related ISO methods and requirements for testing and labelling, including:

• ISO 18664 (heavy metals), ISO 22258 (pesticide residues), ISO 22590 (sulfur dioxide) and ISO 21371 (labelling).

Keywords: ISO 19851, Cinnamomum cassia branch, Traditional Chinese medicine, cinnamaldehyde, TLC identification, HPLC analysis, herbal quality and safety, Chinese materia medica, heavy metals, pesticide residues.