ISO 22412:2025 PDF

Name: ISO 22412:2025 — Particle size analysis — Dynamic light scattering (DLS)
SKU: ISO 22412:2025
Price: 25 EUR
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Particle size analysis — Dynamic light scattering (DLS)

Название (английский):

ISO 22412:2025

Particle size analysis — Dynamic light scattering (DLS)

Статус документа:: Действующий
Формат:: Электронный (PDF)
Количество страниц:: 64
Дата публикации:: 5 сентября 2025 г.
Издание:: ISO IS 22412 edition 3 version 1
ICS:: 19.120

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Описание (английский):

This document specifies the application of dynamic light scattering (DLS) to the following: — measurement of average hydrodynamic particle size; — measurement of the size distribution of mainly sub micrometre-sized particles, emulsions or fine bubbles dispersed in liquids. This document is applicable to the measurement of a broad range of dilute and concentrated suspensions.

Abstract

Похожие стандарты

Стандарты, упомянутые в описании

Overview

ISO 22412:2025 - Particle size analysis - Dynamic light scattering (DLS) specifies how to apply dynamic light scattering for measuring average hydrodynamic particle size and size distributions of mainly sub‑micrometre particles, emulsions and fine bubbles dispersed in liquids. The third edition extends applicability to both dilute and concentrated suspensions and adds multi‑angle and imaging DLS methods. The standard covers instrument requirements, sample preparation, measurement procedures, data evaluation and quality control.

Key technical topics and requirements

Scope and definitions: clear terms for hydrodynamic diameter, polydispersity index (PI), scattering volume, count rate, reference materials and qualification concepts.

Principle and apparatus: fundamentals of DLS measurement geometry, lasers and detectors; differences between homodyne/heterodyne modes and single vs multi‑angle setups.

Sample preparation: guidance on concentration limits, checks for concentration suitability and recommendations for handling dilute and concentrated suspensions (Annex C).

Measurement procedures: stepwise measurement planning, acquisition modes (autocorrelation, cross‑correlation, frequency analysis, spatial correlation) and multi‑angle/online options (Annex B).

Data evaluation methods: correlation analysis (cumulants method), distribution algorithms (NNLS, CONTIN and others), frequency analysis, and advanced approaches such as MADLS (multi‑angle DLS), imaging DLS (IDLS, UIDLS) and polarization‑separated backscatter cross‑correlation.

Quality assurance: system qualification, use of reference materials/CRMs, quality control checks, method precision and measurement uncertainty (Clause 10).

Reporting and artefact guidance: required elements for test reports and annexed guidance on artefacts, interpretation and measurement planning (Annexes D and E).

Practical applications

ISO 22412:2025 is applicable where reliable sub‑micrometre particle sizing is required, including:

Pharmaceutical formulations (suspensions, liposomes, protein aggregates)

Nanomaterials and colloid research (R&D and characterization)

Food and cosmetic emulsions and quality control

Environmental and process monitoring (fine bubbles, wastewater colloids, online process control)

Instrument validation and commercial DLS system development

Who should use this standard

Analytical laboratories and quality control teams performing particle size analysis

Research scientists in colloid, nanoscience and formulation development

Instrument manufacturers and service providers for DLS systems

Regulatory and accreditation bodies assessing measurement traceability and uncertainty

Related standards

ISO 9276 (particle size distribution presentation)

ISO 26824 (terminology)

ISO 17034, ISO 33405, ISO 33401 (reference material and certification guidance)

ISO/IEC Guide 99 (metrological traceability)

Using ISO 22412:2025 ensures standardized, reproducible DLS measurements and supports robust interpretation of hydrodynamic size and distribution data across laboratory and industrial contexts.

ISO 22412:2025 PDF

Abstract

Похожие стандарты

Overview

Key technical topics and requirements

Practical applications

Who should use this standard

Related standards

Технические детали

ISO 9276-4:2001/Amd 1:2017

Representation of results of particle size analysis — Part 4: Characterization of a classification process —…

BS ISO 26824:2013

Particle characterization of particulate systems. Vocabulary

ISO 17034:2016

General requirements for the competence of reference material producers

ISO 33405:2024

Reference materials — Approaches for characterization and assessment of homogeneity and stability

ISO 33401:2024

Reference materials — Contents of certificates, labels and accompanying documentation