ISO 22634-1:2019 PDF

Name: ISO 22634-1:2019 — Cigarettes — Determination of benzo[a]pyrene in cigarette mainstream smoke using GC/MS — Part 1: Method using methanol as extraction solvent
SKU: ISO 22634-1:2019
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Cigarettes — Determination of benzo[a]pyrene in cigarette mainstream smoke using GC/MS — Part 1: Method using methanol as extraction solvent

Название (английский):

ISO 22634-1:2019

Cigarettes — Determination of benzo[a]pyrene in cigarette mainstream smoke using GC/MS — Part 1: Method using methanol as extraction solvent

Статус документа:: Действующий
Формат:: Электронный (PDF)
Количество страниц:: 11
Дата публикации:: 4 декабря 2019 г.
Издание:: ISO IS 22634 edition 2 version 1
ICS:: 65.160

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Описание (английский):

This document specifies a method for the determination of benzo[a]pyrene (B[a]P) in the total particulate matter (TPM) of cigarette mainstream smoke using gas chromatography/mass spectrometry (GC/MS) with methanol as extraction solvent. This method is specified using ISO 3308 smoking parameters. An alternative method for the determination of B[a]P is specified in ISO 22634-2 with a different clean-up using cyclohexane solvent and a shorter total analytical time.

Abstract

Похожие стандарты

Стандарты, упомянутые в описании

Overview - ISO 22634-1:2019 (benzo[a]pyrene in cigarette smoke using GC/MS, methanol)

ISO 22634-1:2019 specifies a validated laboratory method for the determination of benzo[a]pyrene (B[a]P) in the total particulate matter (TPM) of cigarette mainstream smoke. The procedure uses gas chromatography/mass spectrometry (GC/MS) with methanol as the primary extraction solvent and is defined for machine smoking under ISO 3308 parameters. The standard documents sampling, conditioning, extraction, clean-up, GC/MS analysis (single ion monitoring), and calculation procedures, and reports repeatability and reproducibility performance.

Key topics and technical requirements

Scope & principle: TPM collected on glass-fibre filter pads; TPM extracted with methanol, diluted with water, and partitioned onto cyclohexyl solid phase extraction (CH‑SPE) cartridges; B[a]P eluted with cyclohexane and analyzed by GC/MS.

Smoking regime: Method specified using ISO 3308 smoking parameters and related sampling/conditioning standards (ISO 8243, ISO 3402, ISO 4387).

Analytical instrumentation: GC with mass selective detector operated in single ion monitoring (SIM) mode; splitless injection on an appropriate capillary column (example: 5%-phenyl methylpolysiloxane, 30 m × 0.25 mm × 0.25 µm).

Standards & reagents: Preparation and storage of primary/secondary B[a]P and B[a]P‑d12 internal standard solutions; use of high-purity methanol, cyclohexane, toluene, and helium carrier gas.

Quality & performance: Calibration, use of labeled internal standard (B[a]P‑d12), and documented repeatability and reproducibility (updated in the 2019 edition).

Safety: Explicit warning - B[a]P and B[a]P‑d12 are carcinogens; laboratories must apply appropriate safety and containment practices.

Practical applications and target users

Laboratories performing tobacco product chemical characterization, regulatory compliance testing, or research on smoke emissions.

Tobacco manufacturers and quality control labs validating product formulations or emission profiles.

Regulatory agencies and public health laboratories assessing B[a]P levels in mainstream smoke for comparative or surveillance purposes.

Analytical chemistry labs adopting GC/MS methods for PAH (polycyclic aromatic hydrocarbon) quantification in complex matrices.

Practical benefits include a reproducible, collaborative-tested GC/MS workflow for low‑level B[a]P quantification in cigarette TPM and guidance on sample prep, SPE clean‑up, and instrumentation settings to reduce analytical variability.

Related standards

ISO 22634-2 (alternative B[a]P method with cyclohexane clean-up and shorter analytical time)

ISO 3308 (routine analytical smoking machine)

ISO 3402 (conditioning/testing atmosphere)

ISO 4387 (TPM and nicotine-free particulate determination)

ISO 8243 (cigarette sampling)

ISO 3696 (laboratory water quality)

Keywords: ISO 22634-1:2019, benzo[a]pyrene, B[a]P, cigarette mainstream smoke, GC/MS, methanol extraction, TPM, ISO 3308, CH‑SPE.

ISO 22634-1:2019 PDF

Abstract

Похожие стандарты

Overview - ISO 22634-1:2019 (benzo[a]pyrene in cigarette smoke using GC/MS, methanol)

Key topics and technical requirements

Practical applications and target users

Related standards

Технические детали

SIST ISO 3308:2014

Routine analytical cigarette-smoking machine - Definitions and standard conditions

SIST ISO 8243:2014

Cigarettes - Sampling

SIST ISO 3402:2023

Tobacco and tobacco products - Atmosphere for conditioning and testing

SIST ISO 4387:2020

Cigarettes - Determination of total and nicotine-free dry particulate matter using a routine analytical smoki…

BS ISO 22634-2:2019

Cigarettes. Determination of benzo[a]pyrene in cigarette mainstream smoke using GC/MS. Method using cyclohexa…

SIST EN ISO 3696:1998

Water for analytical laboratory use - Specification and test methods (ISO 3696:1987)